Estimation of rodent airway parameters using a two chamber plethysmograph.
Reynolds-JS; Friend-KA; Stolarik-BM; Goldsmith-WT; McKinney-WG; Frazer-DG
Proceedings of the 3rd International Workshop on Biosignal Interpretation, Chicago, IL, June 12-14, 1999. Chicago, IL: University of Illinois 1999 Jun; :162-165
A system was developed to estimate airway parameters of rodents using a two chamber plethysmograph. Rodent respiration in a two chamber flow-flow plethysmograph was modeled as a second order system in the continuous time domain. The model was converted to the equivalent digital filter, and the animal respiratory signals fitted to the filter using a least squares technique. The filter coefficients were then used to calculate the rodent airway parameters. These parameters included the product of airway resistance and thoracic gas compliance, which is a measure of airway constriction. Another calculated parameter was the thermal time constant associated with the heating and cooling of inspired and expired room temperature air.
Analytical-processes; Analytical-methods; Airway-obstruction; Animal-studies; Animals; Laboratory-animals; Pulmonary-function-tests; Respiratory-function-tests; Alveolar-cells; Aerosol-particles; Airborne-dusts; Airborne-particles; Particulate-dust; Respiratory-system-disorders; Pulmonary-system-disorders; Exposure-assessment
Proceedings of the 3rd International Workshop on Biosignal Interpretation, Chicago, IL, June 12-14, 1999