Acute disruption of cochlear potentials by potassium cyanide.
Toxicologist 1999 Mar; 48(1-S):292
Cyanide is present in various environmental settings and is also an occupational hazard for firefighters. Effects and mechanisms of cyanide (CN) toxicity are unclear in hearing 10ss. In this study, adult male Long Evans hooded rats were used to examine the effects of potassium cyanide (KCN). Interactions with noise on cochlear potentials, namely compound action potential (CAP) and cochlear microphonic (CM) were studied. Subjects were injected with KCN (7mg/kg, ip) and compared with controls (saline, ip). CAP sensitivity is dependent upon the function of inner hair cells and spiral ganglion cells. The CM is generated predominantly from outer hair cells. CAP and CM were recorded pre and post administration of KCN. Hearing levels at three frequencies (2 kHz, 12 kHz and 40 kHz) were tested. Blood cyanide levels were measured following KCN administration for a period of 30 min. A temporary threshold shift in both CAP and CM was observed for a period of 5 to 15 min. following KCN administration. Concurrent exposure to KCN and noise (110 dB, broad band) for 2 hours demonstrated no threshold shift in either CAP or CM.
Toxins; Toxicology; Toxic-materials; Laboratory-animals; Animal-studies; Statistical-analysis; Analytical-chemistry; Analytical-methods; Chemical-analysis; Dose-response; Exposure-assessment; Hearing-tests; Hearing-disorders; Hearing-protection; Fire-fighters; Fire-fighting; Hearing-protection; Noise-induced-hearing-loss; Synergistic-effects; Cyanides; Ototoxicity
Disease and Injury: Hearing Loss
The Toxicologist. Society of Toxicology 38th Annual Meeting, March 14-18, 1999, New Orleans, Louisiana
University of Oklahoma, Health Sciences Center, Oklahoma Center for Toxicology, Oklahoma City, Oklahoma