An examination of the biochemical and behavioral effects of MPTP in two snake species.
Temple-JG; Miller-DB; Barthalmus-GT
Toxicologist 1999 Mar; 48(1-S):289
The synthetic neurotoxicant 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induces a Parkinsonian-like syndrome in humans and non-human primates, and also causes similar movement disorders in rodents, fish, amphibians and lizards. In this study, the behavioral and biochemical effects of MPTP were assessed in the black ratsnake Elaphe o. obsoleta and the banded watersnake Nerodia f. fasciata. We report that MPTP induces in E. o. obsoleta a depletion of norepinephrine dopamine and serotonin in fore, mid and hindbrain regions and also impedes righting ability. In N. f fasciata, norepinephrine and dopamine were also depleted by MPTP in all three brain regions, but serotonin was only significantly reduced in the forebrain and righting ability was not affected. This study demonstrates a behavioral and biochemical sensitivity to MPTP in E. o. obsoleta that differs from that in N. f. fasciata. This novel reptilian model is beneficial for assessing central dopaminergic and serotonergic involvement in motor control in the lower vertebrates.
Toxins; Toxicology; Toxic-materials; Laboratory-animals; Animal-studies; Neurotoxins; Neurotoxic-effects; Behavioral-disorders; Behavioral-tests; Biochemical-tests; Sensitivity-testing
The Toxicologist. Society of Toxicology 38th Annual Meeting, March 14-18, 1999, New Orleans, Louisiana