Positional isomers of acetaminophen differentially induce proliferation of cultured breast cancer cells.
Harnagea-Theophilus-E; Miller-MR; Rao-N
Toxicol Lett 1999 Jan; 104(1):11-18
This study demonstrates that acetaminophen (p-acetamidophenol) stimulates proliferation of estrogen-responsive cultured breast cancer cells and assesses if the proliferative activity of p-acetamidophenol is influenced by the IOH moiety position on the benzene ring. The effects of p-, m-, and o-acetamidophenol on cell number and on percentage cells in S phase of the cell cycle were determined for two estrogen receptor positive, human breast cancer cell lines, T47D and MCF7. Therapeutic concentrations of p-acetamidophenol (0.1 mM) significantly increased breast cancer cell proliferation. The relative order of potency of isomers in stimulating proliferation in both cell types was p->m->o-acetamidophenol, indicating the IOH position on the benzene ring influences the proliferation output in cultured breast cancer cells.
Breast-cancer; Cancer; Cell-function; Cell-cultures; Benzenes
Eugenia Harnagea-Theophilus, Department of Pharmacology and Toxicology, West Virginia University, P.O. Box 9142, R.C. Byrd Health Sciences Center, Morgantown, WV 26506-9142