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A 13-C CP/MAS and 31-P NMR study of the interactions of dipalmitoylphosphatidylcholine with respirable silica and kaolin.

Authors
Murray DK; Harrison JC; Wallace WE
Source
J Colloid and Interface Sci 2005 Aug; 288(1):166-170
NIOSHTIC No.
20027436
Abstract
The interaction of silica and kaolin with dipalmitoylphosphatidylcholine (DPPC) has been studied using (13)C and (31)P solid state nuclear magnetic resonance spectroscopy. These studies explore the molecular interactions of these respirable dusts with a model lung surfactant species to characterize silica toxicity in mixed systems. The choline head group of DPPC was found to remain mobile when adsorbed on kaolin, in contrast to an immobile head group on silica. Further, glycerol carbon intensities were greatly diminished relative to that of choline carbons, a result attributed to broadening effects. These preliminary findings suggest that silica toxicity may not be related to choline mobility as previously noted [J. Colloid Interface Sci. 172 (1995) 536-538].
Keywords
Respirable-dust; Silica-dusts; Silicates; Models; Silicosis; Lung; Surfactants; Dust-particles; Dusts; Author Keywords: DPPC; Silica; Kaolin; NMR; Silicosis; Lung surfactant; Silanol; Respirable dust; Dipalmitoylphosphatidylcholine
Contact
National Institute for Occupational Health and Safety, 1095 Willowdale Road, M/S 3030, Morgantown, WV 26505, USA
CODEN
JCISA5
CAS No.
1332-58-7
Publication Date
20050801
Document Type
Journal Article
Email Address
dmurray@cdc.gov
Fiscal Year
2005
Issue of Publication
1
ISSN
0021-9797
NIOSH Division
HELD
Priority Area
Research Tools and Approaches: Exposure Assessment Methods
Source Name
Journal of Colloid and Interface Science
State
WV
Page last reviewed: September 2, 2020
Content source: National Institute for Occupational Safety and Health Education and Information Division