A 13-C CP/MAS and 31-P NMR study of the interactions of dipalmitoylphosphatidylcholine with respirable silica and kaolin.
Murray DK; Harrison JC; Wallace WE
J Colloid and Interface Sci 2005 Aug; 288(1):166-170
The interaction of silica and kaolin with dipalmitoylphosphatidylcholine (DPPC) has been studied using (13)C and (31)P solid state nuclear magnetic resonance spectroscopy. These studies explore the molecular interactions of these respirable dusts with a model lung surfactant species to characterize silica toxicity in mixed systems. The choline head group of DPPC was found to remain mobile when adsorbed on kaolin, in contrast to an immobile head group on silica. Further, glycerol carbon intensities were greatly diminished relative to that of choline carbons, a result attributed to broadening effects. These preliminary findings suggest that silica toxicity may not be related to choline mobility as previously noted [J. Colloid Interface Sci. 172 (1995) 536-538].
Respirable-dust; Silica-dusts; Silicates; Models; Silicosis; Lung; Surfactants; Dust-particles; Dusts;
Author Keywords: DPPC; Silica; Kaolin; NMR; Silicosis; Lung surfactant; Silanol; Respirable dust; Dipalmitoylphosphatidylcholine
National Institute for Occupational Health and Safety, 1095 Willowdale Road, M/S 3030, Morgantown, WV 26505, USA
Research Tools and Approaches: Exposure Assessment Methods
Journal of Colloid and Interface Science