Uncertainty in risk assessment: current efforts and future hopes.
Ann NY Acad Sci 1999 Dec; 895(1):367-372
The incorporation of sampling variability in estimates of excess risk has been part of risk assessment practice for decades. Currently, there is a strong desire to incorporate understanding of biological mechanisms into the models used for exposure assessment and exposure-response modeling. In addition, representing population heterogeneity in the assessment of risks and the identification of sensitive subpopulations is of great concern. Finally, the communication of uncertainty and variability remains a challenge to risk assessors. Based upon the presentations of workshop faculty, a summary of current practice when addressing uncertainty together with conjectures concerning future challenges for addressing uncertainty, are presented.
Risk-analysis; Risk-factors; Statistical-analysis; Analytical-processes; Analytical-methods; Exposure-assessment
National Institute for Occupational Safety and Health, Education and Information Division, Risk Evaluation Branch, 4676 Columbia Parkway, Cincinnati, Ohio 45226, USA
Annals of the New York Academy of Sciences