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Risk factors for female infertility in an agricultural region.
Greenlee-AR; Arbuckle-TE; Chyou-PH
Epidemiology 2003 Jul; 14(4):429-436
Recent studies have suggested that agricultural occupations or exposure to pesticides may impair female fertility. The Fertility Risk Factor Study retrospectively examined agricultural and residential exposures and the risk of female infertility. Cases and controls (N = 322 each) came from women who sought treatment at a large group medical clinic in Wisconsin. Women and their male partners provided information on health, occupational and lifestyle exposures in response to a telephone interview during 1997-2001. Mixing and applying herbicides 2 years before attempting conception was more common among infertile women (odds ratio [OR] = 27; 95% confidence interval [CI] = 1.9-380), as was the use of fungicides (OR = 3.3; CI = 0.8-13). Residing on a farm, ranch or in a rural area during this time period was protective of female fertility. Households supplied with central Wisconsin groundwater were at less risk for infertility than households using municipal sources (OR = 0.6; CI = 0.4-0.9). Behavioral risk factors included alcohol consumption (OR = 1.8; 1.2-2.5), smoking (1.6; 0.9-2.9), passive smoke exposure (1.8; 1.2-2.5), steady weight gain in adult life (3.5; 2.0-6.1), and having a male partner over the age of 40 (4.5; 1.2-16.3). Drinking 3 or more glasses of milk per day was protective of female fertility (0.3; 0.1-0.7). These results suggest that certain agricultural, residential and lifestyle choices may modify the risk of female infertility.
Risk-factors; Risk-analysis; Sex-factors; Agriculture; Pesticides; Occupational-exposure; Occupational-health; Agricultural-industry; Agricultural-workers; Fungicides; Behavior-patterns; Alcoholism; Smoking
Anne R. Greenlee, Marshfield Clinic Research Foundation, 1000 North Oak Avenue, 2R5, Marshfield, WI 54449
Agriculture; Cooperative Agreement
Issue of Publication
Marshfield Medical Research & Education Foundation, Marshfield, Wisconsin
Page last reviewed: March 11, 2019
Content source: National Institute for Occupational Safety and Health Education and Information Division