A priority list of chemicals developed by NIOSH using NTP's carcinogenesis bioassay results.
American Public Health Association 123rd Annual Meeting and Exhibition, San Diego, CA, October 29 - November 2, 1995. Washington, DC: American Public Health Association, 1995 Oct; :138
The National Institute for Occupational Safety and Health reviews information on hazardous chemicals potentially used in the workplace. The constant introduction of new agents requires NIOSH to develop priority systems for allocating NIOSH resources. Chemicals were ranked from the National Toxicology Program's (NTP) bioassay studies which evaluate the toxicological potential, including carcinogenic activity, of selected chemicals in 2 species of animals. Five categories of evidence of carcinogenicity were used by NTP: clear, some, equivocal, negative, and inadequate. Using these 5 categories of evidence, NTP chemicals were prioritized using a two-tiered approach. A numerical score (1 to 5) was first given to each study from the NTP conclusions. Next, an overall priority code (1-17) was devised combining the results of each animal species by gender. Agents carcinogenic in both sexes in 2 animal species/2 strains of the same species were designated priority code "1." NIOSH data showed worker exposure potential to 25 of 41 chemicals from priority code 1. the number of workers ranging from <50 to over 513,000. Control measures afforded to workers ranged from "no control" to a variety of personal, respiratory and/or ventilatory protection. The extent of exposure of workers and control measures used for the prioritized chemicals will assist NIOSH in evaluating the need for further studies or for preparation of informational documents.
Carcinogenesis; Carcinogens; Bioassays; Occupational-exposure; Occupational-hazards; Occupational-health; Statistical-analysis; Animal-studies
Conference/Symposia Proceedings; Abstract
American Public Health Association 123rd Annual Meeting and Exhibition, San Diego, CA, October 29 - November 2, 1995