NIOSHTIC-2 Publications Search
Lead skin absorption and the effects of cleaning procedure with detergents.
Larese Filon F; Maina G; Adami G; Cozzi F; Damian A; Boeniger M
Occupational and Environmental Exposures of Skin to Chemicals, Stockholm, Sweden, June 12 -15, 2005. Morgantown, WV: National Institute for Occupational Safety and Health, 2005 Jun; :1-3
Skin contamination by dusts containing lead and other toxic metals is not generally regarded by many as posing significant risks for absorption and toxic effects. Limited experimental studies suggest that under physiologically relevant conditions metal dusts may ionize, which can increase risks of percutaneous absorption of toxic metals (Stauber 1994, Hostynek 2003, Larese 2004). It is known that polar organic compounds and some metals can appreciably be absorbed through damaged skin but this has not been studied in regards to lead particulate compounds (e.g., PbO, PbO2. etc). Previous in-vivo experiments with inorganic lead compounds indicate absorbtion through the skin (Stauber 1994) but there was previously no information on the effect on absorption of decontamination agents. The aim of our study was to investigate the skin absorption of PbO, the effect of a rapid skin decontamination with two different detergents and the comparative absorption in normal or abraded skin.
Skin-irritants; Skin-exposure; Skin-absorption; Absorption-rates; Occupational-hazards; Occupational-health; Lead-poisoning; Lead-dust; Lead-absorption; Decontamination; Detergents; Particulates; Particulate-dust; Dusts; Aerosol-particles; Aerosols
Occupational and Environmental Exposures of Skin to Chemicals, Stockholm, Sweden, June 12 -15, 2005