The multiple transient dermal dose problem: theory.
Occupational and Environmental Exposures of Skin to Chemicals, Stockholm, Sweden, June 12 -15, 2005. Morgantown, WV: National Institute for Occupational Safety and Health, 2005 Jun; :1-6
Typical workplace dermal exposures can be characterized as multiple transient or intermittent dermal contacts. In this scenario, a given amount of contaminant is in contact with a given area of skin for a given period of time. This cycle is repeated throughout the work day with, in general, different amounts of contaminant in contact with different areas of skin over different time intervals. Here we present solutions for concentration, flux and total mass accumulation for this problem, in which we consider the skin to be a single homogeneous membrane. Analytical solutions are derived in the Laplace domain; numerical methods are required to transform these solutions to the time domain. We show that a simple steady-state solution exists for the total accumulation of contaminant, which is analogous to total systemic uptake. This is the main quantity of interest for dermal risk assessment.
Skin-tests; Skin-irritants; Skin-exposure; Skin-disorders; Skin-absorption; Absorption-rates; Statistical-analysis; In-vitro-studies; In-vitro-study; Exposure-assessment; Risk-analysis
Research Tools and Approaches: Exposure Assessment Methods
Occupational and Environmental Exposures of Skin to Chemicals, Stockholm, Sweden, June 12 -15, 2005