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The transient dermal dose problem.
Frasch HF; Barbero AM
Occupational and Environmental Exposures of Skin to Chemicals, Stockholm, Sweden, June 12 -15, 2005. Morgantown, WV: National Institute for Occupational Safety and Health, 2005 Jun; :1-6
Many experimental measurements of steady-state dermal absorption rates of chemical compounds have been reported, and considerable progress has been made in the prediction of these rates. Most real-world dermal exposures, however, are not steady-state. Unfortunately, much less work has been devoted toward experimental and theoretical understanding of the transient dermal dose situation. Here we consider the following scenario: an amount of chemical is applied to the skin and removed a "short time" later, before significant depletion of the chemical has occurred. This scenario might be mimicked in the workplace, for example, where a worker splashes some chemical on his skin and effectively washes it some time later. Experiments were performed using in-vitro diffusion cells to measure the transient dose dermal absorption of diethyl phthalate. Theoretical predictions are compared with the experimental results as a demonstration of concept.
Skin-tests; Skin-irritants; Skin-exposure; Skin-disorders; Skin-absorption; Absorption-rates; Statistical-analysis; In-vitro-studies; In-vitro-study; Chemical-analysis; Chemical-burns; Chemical-properties; Chemical-processing; Models; Exposure-assessment
Research Tools and Approaches: Exposure Assessment Methods
Occupational and Environmental Exposures of Skin to Chemicals, Stockholm, Sweden, June 12 -15, 2005
Page last reviewed: May 5, 2020
Content source: National Institute for Occupational Safety and Health Education and Information Division