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Diseases caused by asbestos: mechanisms of injury and disease development.
Manning CB; Vallyathan V; Mossman BT
Int Immunopharmacol 2002 Feb; 2(2-3):191-200
Asbestos is a ubiquitous, naturally occurring fiber that has been linked to the development of milgnant and fibrotic disease of the lung and pleura. These diseases may be initiated by injury to epithelial cells and mesthelial cells by asbestos fibers through the formation of reactive oxygen intermediates. Elaboration of oxdants are also a consequence of inflammation, a hallmark of exposure to asbestos after inhalation or injection of asbestos fibers into animals. The type, size, and durability of asbestos fibers may be important in toxicity and pathogenicity of asbestos types. This review discusses the pathways of oxidant generation by asbestos fibers, cell-cell interaction that may initiate and perpetuate inflammation, cytokine release and proliferative responses to asbestos, and cell signaling pathways implicated in these events.
Carcinogenesis; Respiratory-system-disorders; Epidemiology; Pulmonary-cancer; Pulmonary-disorders; Pulmonary-system-disorders; Pulmonary-system; Lung-cancer; Lung-disease; Lung-disorders; Lung-fibrosis; Lung-irritants; Asbestos-fibers; Asbestos-dust; Asbestos-cement; Asbestosis; Carcinogens; Cancer; Animal-studies; Animals; Fibrogenicity; Fibrogenesis; Fibrosis; Pleural-cavity; Bronchial-cancer; Mesothelial-cells; Author Keywords: Asbestos; Cancer; NF-kB
Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA
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Page last reviewed: November 6, 2020Content source: National Institute for Occupational Safety and Health Education and Information Division