Interactions of mercury, selenium, tellurium, and arsenic.
Groth-DH; Stettler-LE; Mackay-GR
Proceedings of the Symposium on Selenium-Tellurium in the Environment, Notre Dame, IN, May 11-13, 1976. Pittsburgh, PA: Industrial Health Foundation, Inc., 1976 May; :85-103
The purpose of this paper is to present some of the published data and some unpublished findings on the biological interactions of selenium (Se) with arsenic (As), mercury (Hg) and tellurium (Te). From the point of view of classical toxicology the experimental data arising from the studies of these interactions appear contradictory and confusing. In particular is the observation that the combined administration of two highly toxic salts, mercuric chloride (HgC12) and sodium selenite (Na2Se03) results in a reduction in toxicity of both chemicals. Not only is that unusual, but at the same time the tissue concentrations of these two elements are not decreased as one might expect, but are greatly increased above the levels achieved by injecting either one alone. Combined with this are the many variables that influence the toxicity of chemicals, namely, (1) nutrition, (2) animal species, (3) route of administration, (4) dose, (5) duration of exposure, (6) sequence of administration, (7) interval between injections, and (8) the chemical compound in which the element occurs. Not all of these variables will be covered in this brief article, but the data will be presented in categories of the effect of each element on the other element's toxicity, tissue concentration and metabolism.
Carcinogenesis; Carcinogens; Organo-metallic-compounds; Physical-properties; Chemical-properties; Metallic-poisons; Selenium-compounds; Arsenic-compounds; Arsenic-poisoning; Tellurium-compounds; Mercury-poisoning; Mercury-compounds; Exposure-assessment; Data-processing; Statistical-analysis; Tissue-culture; Tissue-disorders; Biochemical-analysis; Biochemical-tests; Chemical-properties; Heavy-metals; Heavy-metal-poisoning; Laboratory-animals
7782-49-2; 7440-38-2; 7439-97-6; 13494-80-9
Effects and Dose-Response Relationships of Toxic Metals, Notre Dame, IN, May 11-13, 1976