Laboratory evaluation and field testing of a collection method for 1-bromopropane in exhaled breath.
Hanley-KW; Sanderson-WT; Grote-A
Applying Biomarkers to Occupational Health Practice, Santa Fe, NM, March 24-25, 2003. Atlanta, GA: Centers for Disease Control, 2003 Mar; :9
1-Bromopropane (1-BP) has been marketed as an alternative for ozone-depleting solvents and is in adhesives, cleaning solvents, and aerosol products. Toxicity of 1-BP is poorly understood, but it may be a neurologic, reproductive, and hematologic toxin. Sparse exposure information has prompted NIOSH to conduct a multi-industry study using air, exhaled breath, and urinary metabolite measurements. Exhaled breath analysis can be a powerful, non-invasive tool which is affected by inhalation and dermal exposures. Breath sampling methods must be accurate, sensitive, and unaffected by water vapor to measure trace levels consistently without contamination or deterioration. This study evaluated a practical breath collection method for 1-BP analysis conducted at an off-site laboratory with proper quality control.
Analytical-methods; Analytical-chemistry; Sampling-methods; Biomarkers; Adhesives; Cleaning-compounds; Aerosol-particles; Aerosols; Chromatographic-analysis; Neurotoxic-effects; Reproductive-system-disorders; Hematopoietic-system
Abstract; Conference/Symposia Proceedings
Applying Biomarkers to Occupational Health Practice, Santa Fe, NM, March 24-25, 2003