Is NF-kappaB a culprit in type 2 diabetes?
Biochem Biophys Res Commun 2005 Jun; 332(1):1-3
It has been generally viewed that salicylates ameliorate type 2 diabetes through interfering with the NF-kappaB signaling. Earlier studies indicated that IKKbeta was the key for the development of insulin resistance. However, it was unknown whether IKKbeta itself, or its downstream target, NF-kappaB, plays major roles in insulin resistance. New data suggest that NF-kappaB and NF-kappaB-regulated cytokines are crucial for the diabetogenesis.
Endocrine-system; Endocrine-function; Endocrine-system-disorders; Gene-mutation; Genetic-factors
Biochemical and Biophysical Research Communications