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Cutting fluid formulations influence the dermal disposition of linear alkylbenzene sulfonate (LAS).
Baynes RE; Brooks JD; Barlow BM; Riviere JE
Toxicologist 2002 Mar; 66(1-S):163
Linear alkylbenzene sulfonate (LAS) is often added as a surfactant to cutting fluid formulations to enhance the performance of metal machining operations. Unfortunately, LAS and other cutting fluid additives can cause contact dermatitis in workers in the metalworking industry. The purpose of this study was to assess membrane absorption and deposition of 14C-LAS when topically applied to inert membranes (silastic membranes) and porcine skin in in vitro flow-through diffusion cell system as mineral oil or polyethylene glycol (PEG) mixtures. 14C-LAS mixtures were formulated with 3 other additives; namely, 0 or 2% triazine (TRI), 0 or 5% triethanolamine (TRE), and 0 or 5% sulfurized ricinoleic acid (SRA) as follows: TRI, TEA, SRA, TRI+TEA, TRI+SRA, TEA+SRA, TRI+TEA+SRA. In silastic membranes, LAS absorption ranged from 0.09 - 0.19% dose, and there were no differences between corresponding mineral oil and PEG mixtures. Membrane levels were greatest with TRI only in mineral oil and PEG mixtures. In porcine skin, 14CLAS absorption ranged from 0.06 - 0.32% dose, and there were significant differences between several mineral oil and PEG mixtures. LAS penetration into stratum coneum (SC) was often greater in mineral oil than in PEG mixtures. Surprisingly, LAS absorption was significantly greater in pig skin than in silastic membranes for PEG mixtures containing TRI+ TEA. These observations suggest that although very little LAS is absorbed, cutting fluid components can alter LAS deposition into the SC and skin. Furthermore, chemical-biological interactions in viable skin with synergism with a biocide (TRI) and an amine (TEA) may be important determinants for LAS disposition in skin.
Cutting-oils; Oil-mists; Dermatosis; Detergent-enzymes; Skin-absorption; Skin-exposure; Skin-irritants; In-vitro-studies
Center for Chemical Toxicology Research and Pharmacokinetics (CCTRP), College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606
Disease and Injury: Allergic and Irritant Dermatitis
The Toxicologist. Society of Toxicology 41st Annual Meeting and ToxExpo, March 17-21, 2002, Nashville, Tennessee
North Carolina State University, Raleigh, North Carolina