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DLC-1, a Rho GTPase-activating protein with tumor suppressor function, is essential for embryonic development.
Durkin ME; Avner MR; Huh CG; Yuan BZ; Thorgeirsson SS; Popescu NC
FEBS Lett 2005 Feb; 579(5):1191-1196
DLC-1 (deleted in liver cancer 1) is a Rho GTPase-activating protein that is able to inhibit cell growth and suppress tumorigenesis. We have used homologous recombination to inactivate the mouse DLC-1 gene (Arhgap7). Mice heterozygous for the targeted allele were phenotypically normal, but homozygous mutant embryos did not survive beyond 10.5 days post coitum. Histological analysis revealed that DLC-1-/- embryos had defects in the neural tube, brain, heart, and placenta. Cultured fibroblasts from DLC-1-deficient embryos displayed alterations in the organization of actin filaments and focal adhesions.
Proteins; Cell-growth; Tumorigenesis; Laboratory-animals; Animals; Animal-studies; Histology; Tumors; Tumorigens; Liver-cancer; Pulmonary-system-disorders; Respiratory-system-disorders; Teratogenesis; Teratology; Central-nervous-system-disorders; Cardiovascular-system-disorders; Author Keywords: Rho GTPase-activating protein; Knock-out mouse; Embryonic lethal
Laboratory of Experimental Carcinogenesis, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Bethesda, MD 20892, USA
Issue of Publication
Research Tools and Approaches: Cancer Research Methods
Federation of European Biochemical Societies Letters
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