Effect of acute and chronic exposure to the cleanser, trichloroethylene, on the dermal absoprtion of the biocide triazine.
Yeatts-JL; Baynes-RE; Brooks-JD; Barlow-BM; Riviere-JE
Toxicologist 2005 Mar; 84(Suppl 1):445-446
Triazine is often added to cutting-fluid formulations in the metal machining industry as a preservative that inhibits the growth of biological material. Unfortunately, triazine has been shown to cause contact dermatitis in exposed workers. Trichloroethylene, TCE, is a solvent used for cleaning and rinsing. The purpose of this study was to examine the effect of TCE on the dermal absorption of the biocide triazine. A porcine skin in vitro flow-through diffusion cell system was used for these studies. In one set of experiments, the diffusion cells were dosed topically with 14C-Triazine mixtures containing TCE and the 3 most common cutting-fluid components as aqueous mineral oil (MO) or polyethylene glycol (PEG) mixtures. The cutting-fluid components were 5% linear alkylbenzene sulfonate (LAS), 5% triethanolamine (TEA), and 5% sulfated ricinoleic acid (SRA). In another set of experiments, the diffusion cells were dosed with 14C-Triazine mixtures containing the cutting-fluid components in aqueous MO or PEG-based mixtures after having been pre-exposed in situ to TCE for 96 hours. In the MO-based formulations, the absorption of 14C-Triazine ranged from 3.05 to 3.65% dose. In the PEG-based formulations, the absorption of 14C-Triazine ranged from 2.70 to 4.06% dose. In both sets of experiments, the porcine skin that was pre-exposed in situ to TCE showed greater absorption of 14C-Triazine. The chronic effects of TCE appear to be more important in the PEG-based mixtures than in the MO-based mixtures.
Acute-exposure; Chronic-exposure; Cleaning-compounds; Biocides; Absorption-rates; Triazines; Biological-material; Contact-dermatitis; Dermatitis; Occupational-exposure; Workers; Worker-health; Work-environment; Exposure-levels; Exposure-assessment; Solvents; In-vitro-studies
Disease and Injury: Allergic and Irritant Dermatitis
The Toxicologist. Society of Toxicology 44th Annual Meeting and ToxExpo, March 6-10, 2005, New Orleans, Louisiana
North Carolina State University, Raleigh, North Carolina