Environmental health research in the post-genome era: new fields, new challenges, and new opportunities.
J Toxicol Environ Health, B 2005 Mar-Apr; 8(2):71-94
The human genome sequence provides researchers with a genetic framework to eventually understand the relationships of gene-environment interactions. This wealth of information has led to the birth of several related areas of research, including proteomics, functional genomics, pharmacogenomics, and toxicogenomics. Developing techniques such as DNA/protein microarrays, small-interfering RNA (siRNA) applications, two-dimensional gel electrophoresis, and mass spectrometry in conjunction with advanced analysis software and the availability of Internet databases offers a powerful set of tools to investigate an individual's response to specific stimuli. This review summarizes these emerging scientific fields and techniques focusing specifically on their applications to the complexities of gene-environment interactions and their potential role in environmental biosecurity.
Biological-warfare-agents; Biological-weapons; Infectious-diseases; Genetics; Gene-mutation; Genetic-engineering
X. L. Shi, 1095 Willowdale Rd, MS 2015, Morgantown, WV 26505 USA
Research Tools and Approaches: Cancer Research Methods
Journal of Toxicology and Environmental Health, Part B: Critical Reviews