NIOSHTIC-2 Publications Search
Measurement of Freon-113 exposure dose in exhaled breath samples using GC/MS with preconcentration.
Viscusi DJ; Zhuang ZQ; Shaffer R
Abstr Pap - Am Chem Soc 2004 Aug; 228(Part 1):ANYL-083
In previous work involving half-mask respirators, NIOSH found a correlation between fit factor (a quantitative measure of respirator performance) and total Freon-113 exposure dose (TFED), the amount of Freon-113 in a subject's end-exhaled breath measured 30 minutes after a simulated workplace test. Better detection methods for Freon-113 need to be developed in order to investigate the correlation for other classes of respirators. In this presentation we will describe improved strategies for measuring TFED using gas chromatography-mass spectrometry (GC-MS) with a preconcentration system. This presentation will describe column selection, detection limits, and precision of the analytical method. The effect of critical environmental parameters such as the background level of Freon-113 in the room will also be assessed. The use of GC/MS with preconcentration for exhaled breath analysis and trace detection may find suitability in other applications such as biomarker discovery, industrial hygiene and environmental monitoring.
Sampling-methods; Sample-preparation; Sampling; Refrigerants; Analytical-methods; Analytical-processes; Respirators; Respiratory-protective-equipment; Biomarkers; Industrial-hygiene
NIOSH/NPPTL, 626 Cochrans Mill Road, Pittsburgh, PA 15236
Abstract; Conference/Symposia Proceedings
Abstracts of papers - American Chemical Society
Page last reviewed: May 5, 2020
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