Program No. 236.4. 2004 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2004 Oct; :1
Link
NIOSHTIC No.
20026143
Abstract
Delay discounting is a fundamental behavioral process that may underlie impulsive behavior in both humans and non-humans. Delay discounting refers to decreases in the subjective value of a reward when it is delayed. Impulsive individuals discount the value of delayed rewards more rapidly, reflecting poor control over behavior by delayed consequences. Here we examined the effects of chronic social-defeat stresson delay discounting. AMP has been shown to decrease impulsivity in rats, and animals exposed to chronic social defeat stress exhibit cross-sensitization to the locomotor effects of AMP. In this study we examined the effects of chronic social stresson discounting of delayed rewards and to the locomotor effects of AMP in male C57BL/6 mice. An adjusting amount procedure was used to determine discounting of delayed water rewards (1 Oml delayed by 0, 1, 2, 4 & 8 s). Sixteen mice underwent 10 weeks of chronic social-defeat stress, while being tested on delay discounting daily. A control group (n=16) was tested on delay discounting but not stressed. After completion of the chronic stress regimen mice were tested for locomotor responses to AMP. Compared to controls, the urine of stressed mice had elevated corticosterone. Chronic social defeat stresshad no effect on discounting of delayed rewards, although it did increase the time it took the animals to choose between the immediate and delayed rewards and decreased the number of trials completed. In contrast, chronic stress exhibited greater motor activation after AMP. These results indicate that chronic stressincreases AMP sensitization without increasing impulsive behavior.
Links with this icon indicate that you are leaving the CDC website.
The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website.
Linking to a non-federal website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and products presented on the website.
You will be subject to the destination website's privacy policy when you follow the link.
CDC is not responsible for Section 508 compliance (accessibility) on other federal or private website.
For more information on CDC's web notification policies, see Website Disclaimers.
CDC.gov Privacy Settings
We take your privacy seriously. You can review and change the way we collect information below.
These cookies allow us to count visits and traffic sources so we can measure and improve the performance of our site. They help us to know which pages are the most and least popular and see how visitors move around the site. All information these cookies collect is aggregated and therefore anonymous. If you do not allow these cookies we will not know when you have visited our site, and will not be able to monitor its performance.
Cookies used to make website functionality more relevant to you. These cookies perform functions like remembering presentation options or choices and, in some cases, delivery of web content that based on self-identified area of interests.
Cookies used to track the effectiveness of CDC public health campaigns through clickthrough data.
Cookies used to enable you to share pages and content that you find interesting on CDC.gov through third party social networking and other websites. These cookies may also be used for advertising purposes by these third parties.
Thank you for taking the time to confirm your preferences. If you need to go back and make any changes, you can always do so by going to our Privacy Policy page.