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When is FEV1 loss excessive? - An investigation of the relationship between year-to-year and long-term spirometry changes.

Authors
Wang ML; Avashia B; Petsonk EL
Source
Eur Respir J 2004 Sep; 24(48):434S
NIOSHTIC No.
20026034
Abstract
Spirometry is performed to monitor lung health, but variability between tests can hinder recognition of excessive FEV1 declines. We explored the relationship between year-to-year and long-term (average 18 yrs) FEV1 slopes, using 21,821 results from 1,884 workers who participated in annual spirometry at a chemical plant between 1973 and 2003. Workers with >/=5 valid results over >/= 10 years were included (initial age: mean 35, range 18-62 yrs; 91% male; 35% current smokers, 41% nonsmokers). Long-term FEV1 slopes (ml/yr) were calculated for each worker by simple linear regression using all available results, and compared to year-to-year differences (deltaFEV1) in both % and milliliters. Long-term slopes averaged -29.1 ml/yr (-27, -29, -37 ml/yr for male, and -20, -26, and -27 ml/yr for female non-, ex- and cur- smokers, respectively). Excessive long-term decline was defined by the lower 5th%ile of all individual slopes, -68.0 ml/yr. When interpreting yearly FEV1 change using the 5th%ile of deltaFEV1 (-10% or -360 ml) as normal limits, individuals with abnormal short-term declines are more likely to ultimately show excessive long-term declines (odds ratio=3.8).
Keywords
Pulmonary-system-disorders; Pulmonary-disorders; Respiratory-system-disorders; Mortality-rates; Mortality-data; Mortality-surveys; Epidemiology; Statistical-analysis; Spirometry; Lung-function; Pulmonary-function; Pulmonary-function-tests; Surveillance
Contact
Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, WV
CODEN
ERJOEI
Publication Date
20040901
Document Type
Abstract
Fiscal Year
2004
NTIS Accession No.
NTIS Price
ISSN
0903-1936
NIOSH Division
DRDS
Source Name
European Respiratory Journal. 14th ERS Annual Congress, Glasgow, UK, September 4-8, 2004
State
WV
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