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Mortality patterns in Indiana workers exposed to polychlorinated biphenyls (PCBs).
Ruder AM; Hein MJ; Nilsen N; Waters MA; Laber P; Davis-King K; Prince MM; Whelan E
Am J Epidemiol 2004 Jun; 159(11)(Suppl):S20
Background: Mortality was updated through 1998 for 3,588 workers exposed to polychlorinated biphenyls (PCBs) between 1957 and 1986 at a capacitor manufacturing plant, to evaluate excess melanoma and brain cancer, originally seen in this cohort, and rectal, liver, biliary tract, and gall bladder cancer, and non-Hodgkins lymphoma, observed in other PCB studies. Methods: Standardized mortality ratios (SMR) and 95% confidence intervals (CI) used Indiana state (shown) and U. S. rates. A new job-exposure matrix calculated estimated cumulative exposure. Results: Overall mortality was reduced (547 deaths, SMR 0.81, CI 0.75, 0.88). Melanoma was significantly elevated (9 deaths, SMR 2.43, CI 1.11,4.60); brain cancer (12 deaths, SMR 1.91, CI 0.98, 3.33) and non-Hodgkins lymphoma (9 deaths, SMR 1.23, CI 0.56, 2.33) were elevated. Other cancers of a priori interest were not in excess. When the cohort was stratified by quartiles of estimated cumulative exposure, melanoma was in excess in the lowest quartile (4 deaths, SMR 4.09, CI 1.12, 10.5), with a trend (p = 0.014) of decreasing SMR with increasing exposure. Brain cancer was in excess in the highest quartile (5 deaths, SMR 3.55, CI US, 8.28) but there was no dose response trend. Among 2,789 individuals who worked at least 90 days, both melanoma (8 deaths, SMR 2.66, CI 1.15,24) and brain cancer (II deaths, SMR 2.12, CI 1.06, 80) were in excess. Conclusion: These findings reinforce those of the original study. For both melanoma and brain cancer, mortality and estimated cumulative exposure do not fulfill dose-response relationships.
Epidemiology; Statistical-analysis; Mortality-rates; Mortality-data; Mortality-surveys; Brain-tumors; Skin-cancer; Skin-disorders; Skin-diseases; Central-nervous-system-disorders; Bladder-cancer; Bladder-disorders; Bladder-disease; Gastrointestinal-system-disorders; Gastrointestinal-system; Liver-cancer; Liver-disorders; Liver-tumors; Polychlorinated-biphenyls
Issue of Publication
American Journal of Epidemiology. Society for Epidemiologic Research (SER). Abstracts of the 37th Annual Meeting, Salt Lake City, Utah, June 15-18, 2004