NIOSHTIC-2 Publications Search
Molecular mechanisms of arsenic carcinogenesis.
Huang C; Ke Q; Costa M; Shi X
Mol Cell Biochem 2004 Jan; 255(1-2):57-66
Arsenic is a metalloid compound that is widely distributed in the environment. Human exposure of this compound has been associated with increased cancer incidence. Although the exact mechanisms remain to be investigated, numerous carcinogenic pathways have been proposed. Potential carcinogenic actions for arsenic include oxidative stress, genotoxic damage, DNA repair inhibition, epigenetic events, and activation of certain signal transduction pathways leading to abberrant gene expression. In this article, we summarize current knowledge on the molecular mechanisms of arsenic carcinogenesis with an emphasis on ROS and signal transduction pathways.
Arsenic-compounds; Carcinogenesis; Carcinogenicity; Carcinogens; Metalloids; Cancer; Cancer-rates; Exposure-levels; Genotoxic-effects; Genes; Author Keywords: Arsenic; carcinogenesis; gene expression; reactive oxygen species; genetic toxicity; signal transduction; kinase; methylation
C. Huang, Nelson Institute of Environmental Medicine, New York University School of Medicine, 57 Old Forge Road, Tuxedo, NY 10987, USA
Issue of Publication
Molecular and Cellular Biochemistry
Page last reviewed: September 2, 2020
Content source: National Institute for Occupational Safety and Health Education and Information Division