Acute respiratory distress syndrome and oxidative stress. Mechanisms of disease development and opportunities for antioxidant prevention.
Oxygen/nitrogen radicals: lung injury and disease (Lung biology in health and disease). Vallyathan V, Castranova V, Shi X, eds. New York: Marcel Dekker, 2004 Apr; 187:393-412
ARDS is obviously a complicated disease with a high mortality rate. Although substantial progress has been made in the understanding of the pathophysiology of ARDS, very little attention has been paid to deciphering the fundamental molecular events that trigger the syndrome and its complications. Some of these triggering events are produced and regulated by the balance between oxidants and antioxidants. Because early events initiating the disease are difficult to investigate in humans, experimental models producing appropriate "ARDS-like" oxidant-antioxidant imbalances, complement and cytokine activation, up-regulation of adhesion molecules, recruitment and activation of neutrophils and macrophages, proteases, cytokines, and other recognized mediators of ARDS inflammation and injury will be valuable. In the therapeutic arena, numerous therapeutic regimes targeting the molecular pathways and consequences of oxidant-antioxidant imbalances are needed. The roles of oxidant and antioxidant balance in signaling processes and the effect of genetic and environmental predispositions that affect the oxidant and antioxidant balance are the frontiers in the investigation of ARDS (79). They probably hold new answers to the questions that still confront us about the basic mechanisms responsible for ARDS as well as the persistent clinical puzzles related to why some at-risk individuals develop ARDS while other comparably at-risk patients do not. The parallel question of why some ARDS patients succumb while other seemingly comparable patients do not is also an unsolved mystery at this time.
Antioxidants; Antioxidation; Respiratory-system-disorders; Pulmonary-system-disorders; Lung-disease; Lung-disorders; Lung-function; Pulmonary-function; Chronic-degenerative-diseases
Vallyathan-V; Castranova-V; Shi-X
Research Tools and Approaches: Cancer Research Methods
Oxygen/nitrogen radicals: lung injury and disease (Lung biology in health and disease)