NIOSHTIC-2 Publications Search

A technique for the identification and direct analysis of hexahydro-1,3,5-tris(2-hydroxyethyl)-s-triazine in metalworking fluids using electrospray-mass spectrometry.

Pretty J; Glaser R; Jones J III; Lunsford RA

Analyst 2004 Nov; 129(11):1150-1155

http://dx.doi.org/10.1039/b404578e

20025668

Hexahydro-1,3,5-tris(2-hydroxyethyl)-s-triazine is a widely used biocide in metalworking fluids that resists direct quantification in many analytical methods due to instability. It can be detected in electrospray-mass spectrometry (ES-MS) due to the formation of a charged and relatively stable adduct with the sodium ion. This adduct produces a distinct ion spectrum via collision-induced fragmentation, which should promote specific detection of the analyte in complex matrices. ES-MS detection of the analyte added to, or already present in, metalworking fluid samples at microg mL(-1) levels is demonstrated. Parameters affecting the formation and detection of the sodium adduct, including choice of solvent, alkalinity, and sodium ion level are explored. Linearity of response in flow injection mode is demonstrated.

Metalworking-industry; Metalworking-fluids; Metalworking; Mass-spectrometry; Biocides; Analytical-methods; Sodium-compounds; Sampling; Solvents

U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Applied Research and Technology, 4676 Columbia Parkway, Cincinnati, OH 452

ANALAO

7440-23-5

20041101

Journal Article

JPretty@cdc.gov

2005

11

0003-2654

DART

Research Tools and Approaches: Exposure Assessment Methods

Analyst

OH; LA