Genetic testing of railroad track workers with carpal tunnel syndrome.
Human Genome Epidemiology: A Scientific Foundation for Using Genetic Information to Improve Health and Prevent Disease. New York: Oxford University Press, , 2004 Jan; :511-524
Carpal tunnel syndrome (CTS) is the most common peripheral compression neuropathy with an estimated prevalence of 2.1%. It has a multifactorial etiology involving systemic, anatomic, idiopathic, and ergonomic factors (1-5). Work-related activities have been strongly associated with CTS (4-6). Some of the highest rates of CTS occur in occupations with high work demand or extensive manual exertion such as automobile assembly and meat processing. CTS also occurs in individuals with various health conditions such as rheumatoid arthritis, thyroid disease, diabetes, late pregnancy, and rapid weight loss. CTS often occurs as a result of two hereditary conditions: hereditary neuropathy with liability to pressure palsies (HNPP) and familial amyloidotic polyneuropathy (FAP). Occupational and medical conditions associated with CTS are shown in Tables 29.1 and 29.2, respectively.
Genetics; Genetic-factors; Railroad-industry; Workers; Worker-health; Carpal-tunnel-syndrome; Ergonomics; Etiology; Workplace-monitoring
Book or book chapter
Khoury-MJ; Little-J; Burke-W
Human Genome Epidemiology: A Scientific Foundation for Using Genetic Information to Improve Health and Prevent Disease