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Surveillance, medical screening, and intervention.

Schulte PA
Dis Markers 2004 Jul; 20(1):13-14
Much of molecular epidemiologic research has focused on validating biomarkers, that is, assessing their ability to indicate accurately, exposure, effect, disease, or susceptibility. To be of use in surveillance, medical screening, or interventions, biomarkers must already be validated so that they can be used as outcomes or indicators that can serve a particular function. In surveillance, biomarkers can be used as indicators of hazard, exposure, disease, and population risk. However, to obtain rates for these measures, the population at risk will need to be assessed. In medical screening, biomarkers can serve as early indicators of disease in asymptomatic people. This allows for the identification of those who should receive diagnostic confirmation and early treatment. In intervention (which includes risk communication, risk management, and various prevention efforts), biomarkers can be used to assess the effectiveness of a prevention or control strategy as well as help determine whether the appropriate individuals are assigned to the correct intervention category. Biomarkers can be used to provide group and individual risk assessments that can be the basis for marshalling resources. Critical for using biomarkers in surveillance, medical screening, and intervention is the justification that the biomarkers can provide information not otherwise accessible by a less expensive and easier-to-obtain source of information, such as medical records, surveys, or vital statistics. The ability to use validated biomarkers in surveillance, medical screening and intervention will depend on the extent to which a strategy for evidenced-based procedures for biomarker knowledge transfer can be developed and implemented. This will require the interaction of researchers and decision-makers to collaborate on public health and medical issues.
Surveillance-programs; Medical-screening; Epidemiology; Biomarkers; Exposure-assessment; Hazards; Diseases; Risk-factors; Risk-analysis
Publication Date
Document Type
Conference/Symposia Proceedings; Abstract
Fiscal Year
Issue of Publication
NIOSH Division
Source Name
Disease Markers. ICT X Satellite Meeting on Molecular Epidemiology, Linking Toxicology to Epidemiology - Biomarkers and New Technologies, Haikko, Porvoo, Finland, 8-10 July 2004
Page last reviewed: September 2, 2020
Content source: National Institute for Occupational Safety and Health Education and Information Division