The association between HLA-DPB1Glu69 and chronic beryllium disease and beryllium sensitization.
McCanlies-EC; Ensey-JS; Schuler-CR; Kreiss-K; Weston-A
Am J Ind Med 2004 Aug; 46(2):95-103
Several case-control studies have found an association between chronic beryllium disease (CBD) and HLA-DPB1 gene variants. However, the relationship between HLA-DPB1 and beryllium sensitization, and whether the presence of one or two HLA-DPB1(Glu69) alleles is differentially associated with CBD and beryllium sensitization have not been completely resolved. Restriction fragment length polymorphism (RFLP) analysis was used to address these questions in a large population-based cohort consisting of 884 beryllium workers (90 with CBD, 64 beryllium sensitized). HLA-DPB1(Glu69) was associated with both CBD (OR = 9.4; 95% CI = 5.4, 16.6) and sensitization (OR = 3.3, 95% CI = 1.9, 5.9). Further, workers with CBD and sensitization were more likely to be homozygous HLA-DPB1(Glu69) compared to workers without disease or sensitization (P < 0.001). Follow-up of this cohort, scrutiny of HLA-DPB1 haplotypes, and evaluation of gene-environment and gene-gene interactions will be important for fully understanding the immunogenetic nature of this occupational disease.
Chronic-degenerative-diseases; Beryllium-disease; Beryllium-compounds; Sensitization; Case-studies; Workers; Occupational-diseases; Genes; Occupational-exposure;
Author Keywords: berylliosis; beryllium; chronic beryllium disease; HLA-DP antigens; occupational epidemiology
Ainsley Weston, NIOSH/HELD/TMBB, 1095 Willowdale Road, Morgantown, WV 26505
Research Tools and Approaches: Exposure Assessment Methods
American Journal of Industrial Medicine