Spray-painting and chronic airways obstruction.
Glindmeyer-HW; Lefante-JJ Jr.; Rando-RJ; Freyder-L; Hnizdo-E; Jones-RN
Am J Ind Med 2004 Aug; 46(2):104-111
The aim was to investigate the respiratory response of HDI-based paint aerosol within the context of the protection afforded by current exposure guidelines. A cross-sectional study of 240 painters spraying polyurethane enamels was undertaken at four aircraft maintenance plants. Questionnaire and spirometric data were related to gravimetric measures of cumulative total and respirable paint aerosol (TPA and RPA) and estimated isocyanate in total and respirable aerosols (TIA and RIA). Average cumulative exposures in mg/m(3)-years +/- SD were 159.0 +/- 115.2 TPA, 19.1 +/- 13.8 RPA, 15.8 +/- 11.5 TIA, and 1.9 +/- 1.4 RIA. After adjusting for smoking and asthma symptoms, higher exposures were associated with statistically significant reduction in expiratory flowrates. Significant smoking-related reductions were also observed, without exposure interactions. These results suggest important respiratory effects from exposures to spray paint aerosols at levels generally in compliance with existing standards for otherwise unregulated particulates and for the isocyanate component of the paint.
Spray-painting; Paint-spraying; Paints; Airway-obstruction; Aerosols; Exposure-assessment; Aircraft; Questionnaires; Smoking; Respiratory-system-disorders; Particulates; Isocyanates; Pulmonary-system-disorders; Lung-function; Surveillance;
Author Keywords: isocyanate exposure; spray-paint; cross-sectional; lung function; chronic obstructive pulmonary disease
Henry W. Glindmeyer, Professor of Medicine, Section of Pulmonary, Critical Care, and Environmental Medicine, Tulane School of Medicine, Room 204, 1324 Tulane Avenue, New Orleans, LA 70118
Disease and Injury: Asthma and Chronic Obstructive Pulmonary Disease; Construction
American Journal of Industrial Medicine