NIOSHTIC-2 Publications Search

The effect of age and testosterone on the expression of glial fibrillary acidic protein in the rat cerebellum.

Authors
Day JR; Frank AT; O'Callaghan JP; Jones BC; Anderson JE
Source
Exp Neurol 1998 Jun; 151(2):343-346
NIOSHTIC No.
20025328
Abstract
Testosterone reversed the age-related increase in glial fibrillary acidic protein (GFAP) in the male rat cerebellum, a brain region not generally associated with gonadal steroid hormone sensitivity. This supports the hypothesis that a decrease in circulating testosterone contributes to age-related increase in GFAP. These data also suggest that reductions in circulating gonadal steroids during aging could render the brain more susceptible to neurodegeneration and that hormone replacement therapy might have value in neurodegenerative disease intervention.
Keywords
Hormones; Hormone-activity; Proteins; Brain-function; Brain-matter; Disease-prevention; Diseases; Age-factors; Age-groups; Author Keywords: GFAP; astrocytes; testosterone; aging; cerebellum; rat
CODEN
EXNEAC
Publication Date
19980601
Document Type
Journal Article
Fiscal Year
1998
Issue of Publication
2
ISSN
0014-4886
NIOSH Division
HELD
Source Name
Experimental Neurology
State
WV
Page last reviewed: May 5, 2020
Content source: National Institute for Occupational Safety and Health Education and Information Division