Astrocytes: key players in mediation or modulation of neurotoxic responses? Commentary on forum position paper.
Neurotoxicology 1998 Feb; 19(1):35-36
Aschner (1998) presents an excellent overview of specific aspects of astrocyte physiology/pathology that may playa role in the induction and exacerbation of neuronal dysfunction. Glia in general, and astrocytes and microglia in particular, are gaining increasing attention in the neuroscience community. They are no longer thought of as "nerve glue" but are viewed as multifunctional neural cells with diverse physiological functions based on both in vivo and in vitro data. A forum on glia function in physiology and pathology is difficult, therefore, given the breadth and depth of the subject matter. Any attempt to review such a broad subject in a short article will inevitably provide coverage of some areas at the expense of others. The present review is no exception, yet Aschner manages to focus attention on important and overlooked issues with respect to the role of astrocytes in neurotoxic responses.
Physiological-function; Physiological-factors; Physiological-effects; Physiological-response; Pathology; Neuropathology; Neuropathy; Neurological-system; Nerve-tissue; Nerve-fibers; Nerve-function; Nerves; In-vivo-study; In-vitro-study
Dr. James P O'Callaghan, Molecular Neurotoxicology Laboratory, Toxicology and Molecular Toxicology Branch, Health Effects Laboratory Division, Centers for Disease Control and Prevention-NIOSH, 1095 Willowdale Road, MSL3014, Morgantown WV, 26505