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DARPP-32: regulator of the efficacy of dopaminergic neurotransmission.
Fienberg-AA; Hiroi-N; Mermelstein-PG; Song-WJ; Snyder-GL; Nishi-A; Cheramy-A; O'Callaghan-JP; Miller-DB; Cole-DG; Corbett-R; Haile-CN; Cooper-DC; Onn-SP; Grace-AA; Ouimet-CC; White-FJ; Hyman-SE; Surmeier-DJ; Girault-J-A; Nestler-EJ; Greengard-P
Science 1998 Aug; 282(5378):838-842
Dopaminergic neurons exert a major modulatory effect on the forebrain. Dopamine and adenosine 3',5'-monophosphate-regulated phosphoprotein (32 kilodaltons) (DARPP-32), which is enriched in all neurons that receive a dopaminergic input, is converted in response to dopamine into a potent protein phosphatase inhibitor. Mice generated to contain a targeted disruption of the DARPP-32 gene showed profound deficits in their molecular, electrophysiological, and behavioral responses to dopamine, drugs of abuse, and antipsychotic medication. The results show that DARPP-32 plays a central role in regulating the efficacy of dopaminergic neurotransmission.
Brain-function; Brain-matter; Animals; Animal-studies; Proteins; Molecular-biology; Molecular-structure; Behavior; Behavior-patterns; Drug-interaction; Drugs
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