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Influence of cutting fluid contaminants on the dermal disposition of the biocide, triazine.
Baynes RE; Brooks JD; Beth B; Wilkes R; Riviere JE
Toxicologist 2004 Mar; 78(S-1):326
Cutting fluids can become contaminated with metals (e.g., nickel, Ni) and nitrosamines (e.g., N-nitrosodiethanolamine, NDELA), and there is concern that these classes of contaminants will modulate dermal disposition and ultimately the toxicity of cutting fluid additives such as biocides (e.g., triazine, TRI). Biocides are added to these formulations to prevent bacterial degradation of commercial cutting fluids. The purpose of this study was to assess the dermal absorption and deposition of C14-TRI when topically applied to porcine skin in an in vitro flow-through diffusion cell system as mineral oil (MO) or polyethylene glycol (PEG) mixtures. C14-TRI mixtures were formulated with NDELA and/or Ni or with 3 other cut-ting fluid additives (5% linear alkylbenzene sulfonate, 5% triethanolamine, and 5% sulfurized ricinoleic acid) and one or both of these contaminants. C14-TRI absorption ranged from 2.72 - 3.29% dose in MO and 2.29 - 2.88% dose in PEG with significantly greater TRI absorption in MO than PEG when all additives and contaminants were present. TRI permeability was consistently and significantly greater in MO than in PEG when NDELA was present. Ni appears to have little or no effect on TRI absorption, although the trends suggest a possible negative effect on triazine permeability and deposition in skin. These observations suggest that metal-machining workers should not only be concerned about dermal toxicity of these contaminants, but they may also enhance dermal disposition of cutting fluid additives.
Biocides; Triazenes; Fluids; Nitrosamines; Bacteria; In-vitro-studies; Mineral-oils; Metalworking-industry; Metalworking-fluids
Disease and Injury: Allergic and Irritant Dermatitis
The Toxicologist. Society of Toxicology 43nd Annual Meeting and ToxExpo, March 21-25, 2004, Baltimore, Maryland
North Carolina State University, Raleigh, North Carolina