Reproductive activity of adult mice treated neonatally with methoxychlor (technical grade).
FASEB J 1995 Mar; 9(3)(I):A550
This study is designed to determine the ability of female mice exposed neonatally to the pesticide methoxychlor, to mate, ovulate and become pregnant as adults. One-day-old female mice were exposed daily for 14 days to either sesame oil or 10 ug estradiol-17B (E) or 0.1,0.5 or 1.0 mg MXC suspended in sesame oil. Three months later female mice were placed with males and checked daily for plugs. Mated mice were sacrificed 18 days following the appearance of a vaginal plug to evaluate pregnancy. Uteri were examined for the presence of fetuses and resorption sites. Ovaries were removed and prepared for histological evaluation and tabulation of corpora lutea. Mice from all three MXC-treated groups mated whereas no E-treated mice did. With increasing dose of MXC there was a decrease in the number of pregnant animals observed at 18 days following mating. The mean number of live young was significantly reduced in the 0.5 and 1.0 mg MXC-treated groups with resorption sites found in most. Corpora lutea were significantly reduced in ovaries from these mice. It is concluded that neonatal exposure to MXC does not interfere with mating but does exert a significant effect on pregnancy. This may result from a significant decrease in the number of healthy oocytes ovulated and/or from a failure the uterus to accept and retain the fertilized egg.
Reproductive-effects; Reproductive-hazards; Reproductive-system-disorders; Laboratory-animals; Insecticides; Toxic-effects; Pesticides; Pregnancy; Prenatal-exposure; Risk-factors; Exposure-levels; Dose-response; Animals; Animal-studies
Abstract; Conference/Symposia Proceedings
The FASEB Journal. Experimental Biology 95 - Annual Meeting of Professional Research Scientists, Atlanta, Georgia, April 9-13, 1995
Louisiana State University, School of Medicine, Department of Anatomy, New Orleans, Louisiana