Validation of the mixed tank reactor model for aerosol dispersion in the lung.
Khandare-P; McCawley-M; Zondlo-J
Ann Occup Hyg, Inhaled Particles VII 1994 Jan; 38(Suppl 1):151-158
The two-parameter 'gamma distribution model with by-pass' (GDMWB) is employed to represent regional ventilation patterns in the lung. One parameter, p, relates to the convective transport ability of the lungs and is directly proportional to the Peclet number, N(pe). The second parameter, B, accounts for the non-homogeneity of ventilation and is the fraction of aerosol undergoing mixing which is reflected in an increased regional time constant due to airway obstruction in the diseased lung. The findings indicate that the parameter B describes the mechanism of the gas transport as expected and is most sensitive to the noise in the data while the parameter B relates to the amount of gas being distributed to the lung's alveoli and is found to be equal to 1.0 for asymptomatic subjects and significantly less in symptomatic subjects.
Ventilation; Lung; Lung-function; Aerosols; Aerosol-particles; Lung-disease; Lung-disorders; Lung-irritants; Oxygen-transport; Oxygen-uptake
National Institute for Occupational Safety and Health, 944 Chestnut Ridge Road, Morgantown, WV 26505, USA
Annals of Occupational Hygiene, Inhaled Particles VII