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Male reproductive effects of lead, including species extrapolation for the rabbit model.
Moorman WJ; Skaggs SR; Clark JC; Turner TW; Sharpnack DD; Murrell JA; Simon SD; Chapin RE; Schrader SM
Reprod Toxicol 1998 May; 12(3):333-346
The effects of elevated blood lead on semen quality were evaluated in the rabbit model and compared to published effects in humans. Mature, male rabbits were given lead acetate by subcutaneous injection in the dose range of 0 to 3.85 mg/kg on a Monday-Wednesday-Friday basis. In each of eight treatment groups, a dosing regimen was developed to produce blood lead levels of 0, 20, 40, 50, 70, 80, 90, and 110 g/dL. A 5-week pre-exposure period was followed by a 15-week exposure testing period allowing for response through six cycles of the seminiferous epithelium. Semen analyses revealed that increased blood lead levels were associated with adverse changes in the sperm count, ejaculate volume, percent motile sperm, swimming velocities, and morphology. Hormonal responses were minimal. Testicular pathology revealed a dose-dependent inhibition of spermiation. For six measures of semen quality, threshold estimates ranged from 16 to 24 g/dL. Using the species extrapolation factor derived in this study, a rabbit dose would have to be divided by 1.56 to obtain the equivalent human dose for an equal percentage decrease in sperm concentration; however, rabbits are 3.75 more sensitive in terms of absolute decrease in sperm count for a given blood lead level.
Lead-compounds; Animal-studies; Animals; Blood-samples; Blood-analysis; Blood-tests; Spermatozoa; Reproductive-effects; Reproductive-system-disorders; Reproductive-hazards; Men; Author Keywords: lead; rabbit model; semen quality; blood lead
William J Moorman, 4676 Columbia Parkway, MS C23: Cincinnati, Ohio 45215
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