Inflammation, tumor necrosis factor, and toxicology.
Environ Health Perspect 1998 Sep; 106(9):A418-A419
At the recent Society of Toxicology annual meeting in March, Debra Laskin of Rutgers University presented the Burroughs Wellcome Toxicology Scholars Award Lecture titled "Mechanisms of Chemical Toxicity: The Dark Side of the Immune System," which described the role of inflammatory processes in exacerbating hepatotoxicity after use of the common pain reliever acetaminophen. The role of inflammation in toxicological responses is viewed with considerable interest by many immunologists and toxicologists as more diseases--ranging from arthritis and Alzheimer's to idiopathic pulmonary fibrosis and chronic hepatitis--manifest an inflammatory component that increases, albeit to a varying degrees, disease severity.
Chemical-reactions; Immune-system; Tumors; Toxicology; Hepatotoxicity; Tissue-disorders; Pulmonary-congestion; Pulmonary-system-disorders
Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
Environmental Health Perspectives