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Vanadium- and chromium-induced cell signal transduction.
Oxygen/nitrogen radicals: lung injury and disease (Lung biology in health and disease). Vallyathan V, Castranova V, Shi X, eds. New York: Marcel Dekker, 2004 Apr; 187:475-492
Both vanadium and chromium are two common toxic metals. Accumulating evidence indicates that exposure of humans to either metal induces a wide spectrum of adverse effects, including carcinogencity. neurotoxicity. and immunotoxicity. Among these adverse effects, carcinogencity is the major geological consequence. The underlying molecular mechanisms have not been fully identified yet. For the past several years, much attention has been focused on how these two metals alter cellular signal transduction to lead to carcinogenesis. This chapter will serve as a summary of recent advances in the knowledge base for cellular signal transduction, including induction of tyrosine phosphorylation. phosphatidylinositol 3-kinase (PI3 kinase) signaling, nuclear factor-kB (NF-kB) activation, cell cycle arrest, and apoptosis,in response to vanadium or chrominum.
Vanadium-compounds; Chromium-compounds; Metals; Toxins; Toxic-effects; Toxic-materials; Carcinogenicity; Carcinogenesis; Cell-function; Cellular-reactions; Neurotoxic-effects; Neurotoxins; Immunotoxins
Vallyathan-V; Castranova-V; Shi-X
Oxygen/nitrogen radicals: lung injury and disease (Lung biology in health and disease)
Page last reviewed: April 12, 2019
Content source: National Institute for Occupational Safety and Health Education and Information Division