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Cellular responses in exertion-induced skeletal muscle injury.
Stauber WT; Smith CA
Mol Cell Biochem 1998 Feb; 179(1-2):189-196
Muscle injury is a common result of muscle exertion caused by overload and over-activity. In this presentation, an attempt was made to discuss models of muscle injury which involve exertion but not excessive strain, although most functional activities of the extremities require some eccentric muscle actions. Muscle injury is characterized by cellular and extracellular matrix responses which appear to be common to all types of muscle trauma -- even in the absence of bleeding. Using tenotomy and functional over-load of the rat hindlimb muscles as examples, illustrations of several of these responses are presented and discussed.
Cellular-reactions; Musculoskeletal-system-disorders; Injuries; Skeletal-system-disorders; Skeletal-disorders; Muscle-stress; Models; Laboratory-animals; Animals; Animal-studies; Author Keywords: skeletal muscle; injury; myofibers; extracellular matrix; exertion; rat
W.T. Stauber, Department of Physiology, Robert C. Byrd Health Sciences Centre, West Virginia University, PO Box 9229, Morgantown, WV 26506-9229, USA
Issue of Publication
Disease and Injury: Musculoskeletal Disorders of the Upper Extremities
Molecular and Cellular Biochemistry
West Virginia University, Morgantown, West Virginia
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