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Fibrosis and intercellular collagen connections from four weeks of muscle strains.
Stauber WT; Knack KK; Miller GR; Grimmett JG
Muscle Nerve 1996 Apr; 19(4):423-430
The effect of repeated cycles of muscle strain was studied in the soleus muscle of female rats. Muscle strains were repeated 3X/week for 1 month using two different strain protocols. Striking changes, including marked variability in fiber size, evidence of degradation and regeneration, and an expanded extracellular matrix were pronounced in the fast-stretched muscles but not in the slow-stretched muscles. However, the slow-stretched muscles did contain struts of connective tissue joining adjacent myofibers. Therefore, repeated muscle strains at high strain rates produced morphological changes similar to many myopathies, including fibrosis, whereas adaptation occurred in response to the same number of strains at slow strain rates. Such diverse tissue responses have relevance to the understanding of the mechanisms of skeletal muscle dysfunction in cumulative trauma disorders and in the design of preventive actions and treatments.
Fibrosis; Collagen fibrils; Muscle stress; Laboratory animals; Animals; Animal studies; Morphology; Cumulative trauma; Cumulative trauma disorders; Musculoskeletal system disorders; Muscle tissue; Injury prevention; Author Keywords: skeletal muscle; strains; fibrosis; collagen; matrix
William T. Stauber, PhD, Department of Physiology, West Virginia University, PO Box 9229, Morgantown, WV 26506-9229
Issue of Publication
Muscle & Nerve
West Virginia University, Morgantown, West Virginia
Page last reviewed: April 9, 2021
Content source: National Institute for Occupational Safety and Health Education and Information Division