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Modeling the mechanical response of chondrocytes to cyclic loading in unconfined compression.
Wu JZ; Herzog W
International Society of Biomechanics, XIXth Congress. Wollongong, NSW, Australia: International Society of Biomechanics, 2003 Jul; :425
Chondrocytes modulate their metabolic activity, in part, in response to their mechanical environment. To understand the mechanism of cartilage degeneration and remodeling, it is important to know the mechanical stimuli to chondrocytes for physiological loading conditions. Fluid pressure and stress-strain state in and around chondrocytes are important mechanical stimuli associated with remodeling, adaptation. and degeneration of articular cartilage. Experimental studies have indicated that cyclic compressive loads stimulate the biosynthetic activity of cells differently than static compressive loads. However, only the overall response of cartilage to dynamic loading has been observed to date. The purpose of the present study was to simulate numerically the location- and time-dependent stress-strain state and fluid pressure distribution in chondrocytes in unconfined compression tests under cyclic loading conditions.
Models; Physiological-factors; Musculoskeletal-system-disorders; Musculoskeletal-system; Repetitive-work; Cumulative-trauma
Disease and Injury: Musculoskeletal Disorders of the Upper Extremities
International Society of Biomechanics, XIXth Congress
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