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The Upper Midwest Health Study: a case-control study of primary intracranial gliomas among rural residents: demographics.
Ruder AM; Waters MA; Carreon T; Butler MA; Davis-King KE; Calvert GM; Schulte PA; Ward EM; Connally LB; Lu J; Wall D; Zivkovich Z; Heineman EF; Mandel JS; Morton RF; Reding DJ; Rosenman KD
Am J Epidemiol 2003 Jun; 157(11):S14
Glioma etiology remains ambiguous, except for ionizing radiation risk. Several studies indicated farmers have excess brain cancer risk. The Upper Midwest Health Study examines intracranial glioma risk in non-urban populations in 4 states. This population-based case-control study includes histologically confirmed cases 18-80 at diagnosis frequency matched to controls selected from driver's license ages 18-64) or HCFA (ages 65-80) records. Over 90% of 873 eligible cases and over 70% of 1670 eligible controls participated. Interviews for 799 cases and 1176 controls collected farm, occupational, residential, and reproductive (women only) histories, as well as lifestyle, medical and family history data. Over 900 blood specimens and 550 post-operative tumor tissues were obtained. This is the largest case control glioma study to date focusing on non-urban populations. Participating and refusant controls differed significantly in farming and job experience, ethnicity, education, and lifestyle. Controls were significantly older than cases, spent a significantly greater part of their lives in non-urban counties and on farms; and were more likely to have exposure to insecticides and farm animals; analyses will adjust for or be stratified by age and residence. Our a priori decision to conduct analyses with and without proxy responses will adjust for the greater than 40% of case proxy interviews.
Epidemiology; Demographic-characteristics; Agricultural-workers; Agricultural-chemicals; Farmers; Age-factors; Sex-factors; Racial-factors; Pesticides-and-agricultural-chemicals; Pesticides
Issue of Publication
American Journal of Epidemiology
OH; GA; IA; MI; MN; WI
Page last reviewed: October 26, 2020
Content source: National Institute for Occupational Safety and Health Education and Information Division