Biological monitoring for exposure to coal tar.
A major goal of biological monitoring for exposure to genotoxic agents is to identify occupations as well as individuals at elevated risk for cancer development. Methods for the detection of carcinogen-DNA and protein adducts have been established. These methods require the collection of blood or tissue samples and are not practical for routine occupational monitoring. In this proposal, methods have been developed for the determination of exposure to benzo(a)pyrene (BP) by measurement of BP and its metabolites in urine. Since urine is much more readily collected than blood, this method should simplify workplace screening.
Biological-monitoring; Coal-tar; Occupational-exposure; Risk-analysis; Risk-factors; Cancer; Genotoxic-effects; Carcinogens; Blood-samples; Benzopyrenes; Workplace-monitoring
Regina M. Santella, Columbia University, Division of Environmental Science, 650 West 168th Street, New York, NY 10032
Final Grant Report
National Institute for Occupational Safety and Health
Columbia University, Division of Environmental Science, New York, New York