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Epidemiologic evaluation of childhood Leukemia and paternal exposure to ionizing radiation.

Sever-LE; Gilbert-ES; Tucker-K; Greaves-J; Greaves-C; Buchanan-J
NIOSH 1997 Oct; :1-51
This project examined cases of three major categories of childhood cancers in the populations around three United States Department of Energy (DOE) facilities to examine the hypothesis of an association between childhood cancer risk and paternal preconception of occupational radiation exposure. This hypothesis was based on the finding of such an association in the population around the Sellafield nuclear facility in England (Gardner et al. 1990a). In an attempt to identify the cause of a cluster of childhood cancers in the vicinity of the Sellafield nuclear plant in West Cumbria, Gardner et a!. (1990a, 1990b) conducted a case-control study of cases of leukemia and non-Hodgkin's lymphoma. Examining a wide variety of risk factors, the authors demonstrated that relative risks for leukemia and non-Hodgkin's lymphoma were higher in children born near Sellafield and in children of fathers employed at the facility, particularly fathers with high radiation dose recordings before conception. Gardner et al. (1990a, 1990b) included all known cases of leukemia and non-Hodgkin's lymphoma among residents of the West Cumbria Health Authority who were diagnosed between the years of 1950 and 1985, were born in the area, and were under the age of 25 years at the time of diagnosis.
Cancer; Cancer-rates; Leukemogenesis; Children; Lymphatic-system-disorders; Radiation-exposure; Radiation-facilities; Nuclear-energy; Nuclear-power-plants; Case-studies; Risk-factors
Battelle Memorial Institute, Seattle Research Center, 4000 N. E. 41st Street, Seattle, WA 98105
Publication Date
Document Type
Final Cooperative Agreement Report
Funding Amount
Funding Type
Cooperative Agreement
Fiscal Year
Identifying No.
Priority Area
Research Tools and Approaches; Risk Assessment Methods
Source Name
National Institute for Occupational Safety and Health
Performing Organization
Battelle Memorial Institute, Seattle Research Center, Seattle, Washington
Page last reviewed: September 2, 2020
Content source: National Institute for Occupational Safety and Health Education and Information Division