Human reproductive endocrine effects of occupational solvent exposure.
Faustman EM; Luderer U; Brodkin CA; Kalman D; Morgan MS
Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, R03-OH-003468, 2000 Feb; :1-19
Although organic solvents are widely used in many different industries, there is very little data on the effects of exposure to all but a few solvents on male reproductive health. Painters comprise one large occupational group with significant solvent exposure that has not been wellstudied in this regard. We therefore chose to study fertility and reproductive endocrine function in male painters. We assessed time-to-pregnancy (fecundability, an indicator of fertility) using a retrospective cohort design and cross-sectionally measured reproductive hormone concentrations in a group of painters compared to a control group of carpenters and to a group of millwrights with intermediate solvent exposure. Detailed occupational, exposure, medical, and time-topregnancy histories were obtained by telephone interview using previously validated instruments. Blood samples were obtained, and serum luteinizing hormone (LH), follic1estimulating hormone (FSH), and testosterone concentrations were determined by immunoassay. Whole blood lead was also measured. Using Cox regression analysis we found that time-topregnancy was non-significantly longer in the painters and millwrights than the carpenters (relative probability of pregnancy in the painters and millwrights combined compared to the carpenters of 0.76, 95% CI 0.45-1.27). In the multivariate analysis time-to-pregnancy was significantly affected by age of the father at the time of the pregnancy of interest and whether the couple was trying to become pregnant. Using analysis of covariance, LH, FSH, and testosterone concentrations did not differ by exposure group, but LH varied significantly with body mass index and education, and testosterone varied significantly with body mass index. The nonsignificantly reduced fecundability in the two solvent-exposed groups suggests the need for further study of fertility in solvent-exposed men.
Endocrine-system-disorders; Reproductive-effects; Reproductive-system-disorders; Painters; Men; Organic-solvents; Fertility; Hormones; Blood-sampling; Occupational-exposure; Statistical-analysis; Epidemiology; Exposure-limits; Toluenes
University of Washington, Department of Environmental Health, Seattle, WA 98105
108-88-3; 1330-20-7; 111-65-9; 78-93-3; 123-86-4; 8052-41-3
Final Grant Report
Disease and Injury: Fertility and Pregnancy Abnormalities
Human reproductive endocrine effects of occupational solvent exposure
University of Washington, Department of Environmental Health, Seattle, Washington