Models for assessing risk of occupational hearing loss.
NIOSH 2000 Nov; :1-9
The research undertaken under this grant was designed to determine the ability of the chemical asphyxiants, carbon monoxide and cyanide, to potentiate noise induced hearing loss. Such mixed exposure to noise and asphyxiant can be predicted to occur in a number or workplace settings such as those that firefighters and truck drivers experience. The results of experiments conducted in rats demonstrate that these asphyxiants do potentiate noise induced hearing loss in a concentration dependent fashion and with an estimated lower bound benchmark concentration of approximately 200-300ppm. Asphyxiants may also increase vulnerability under conditions of intermittent noise exposure. A probable mechanism responsible for potentiation of noise induced hearing loss by asphyxiants is enhancement of free radical species with subsequent tissue damage.
Noise induced hearing loss; Chemical reactions; Ototoxicity; Hearing loss; Noise exposure; Free radical generation; Free radicals; Tissue disorders
University of Oklahoma, Health Sciences Center, Oklahoma Center for Toxicology, P.O. Box 26901, Oklahoma City, OK 73190
Final Grant Report
NTIS Accession No.
Disease and Injury: Hearing Loss
National Institute for Occupational Safety and Health
University of Oklahoma, Health Sciences Center, Oklahoma Center for Toxicology, Oklahoma City, Oklahoma