Respiratory carcinogenesis in uranium miners.
NIOSH 1999 Nov; :1-21
This final report documents an integrated program of an investigation of lung cancer based on the research opportunity afforded by former uranium miners in New Mexico and Colorado. The program included an investigation of the quantitative risks of lung cancer in relation to exposure to radon progeny, of the determinants of susceptibility, and of molecular and cellular markers of carcinogenesis. Uranium miners have been shown to be at a markedly increased excess risk of lung cancer resulting from exposure to radon progeny and smoking. The states of New Mexico, Colorado, Arizona, and Utah have large numbers of former miners who are now at high risk for lung cancer because of these exposures. We have investigated the risks of lung cancer in a cohort of 3,500 New Mexico uranium miners and in Navajo uranium miners. We conducted a research program that extends these studies using a molecular epidemiology model. The program drew on the epidemiological resources of the New Mexico Tumor Registry, a participant in the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) program, and the Cancer Research and Treatment Center at the University of New Mexico as well as molecular and cellular biology resources at the Lovelace Inhalation Toxicology Research Institute. Dr. Frank Gilliland continues as a principal investigator and collaborator in an interdisciplinary research team that is implementing an expanding program on the molecular epidemiology of lung cancer in uranium miners and other high risk groups.
Carcinogenesis; Uranium-compounds; Uranium-miners; Uranium-mining; Miners; Mining-industry; Respiratory-system-disorders; Lung-cancer; Exposure-levels; Risk-analysis; Risk-factors
Frank D. Gilliland, Ph.D, University of New Mexico, New Mexico Tumor Registry, Department of Medicine, 900 Camino de Salud, N.E., Albuquerque, New Mexico, 87131-5306
Final Grant Report
NTIS Accession No.
National Institute for Occupational Safety and Health
University of New Mexico, Department of Medicine, Albuquerque, New Mexico