IL-1Beta Gene Polymorphisms Influence Hepatitis B Vaccination.
Yucesoy-B; Sleijffers-A; Kashon-M; Garssen-J; de Gruijl-FR; Boland-GJ; van Hattum-J; Simeonova-PP; Luster-MI; van Loveren-H
Vaccine 2002 Aug 20(25-26):3193-3196
Considerable variability exists in the vaccine response to hepatitis B with 5-10% of healthy young adults demonstrating no or inadequate responses following a standard vaccination schedule. As the interleukin-1beta (IL-1beta) cytokine has been shown to be important in the development of immune responses, we determined whether vaccine efficacy is influenced by genetic polymorphisms associated with IL-1beta expression. Ninety-two healthy individuals who were negative for antibodies to hepatitis B antigen (anti-HBs) were vaccinated against hepatitis B according to a standardized schedule. At selected times, antibody titers and lymphoproliferative capacity to hepatitis B surface antigen (HBsAg) were determined. DNA genotyping for IL-1beta polymorphisms using a polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP) technique demonstrated that both the anti-HBs titer and the T-cell lymphoproliferative response to HBsAg are significantly increased in individuals possessing the IL-1beta (+3953) minor allelic variant.
Liver; Liver-cancer; Infection-control; Infectious-diseases; Viral-infections; Viral-diseases; Bloodborne-pathogens
National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26508
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