Determination of dialkyldithiocarbamate accelerator residues in latex condoms.
Depree-GJ; Siegel-PD; Bledsoe-TA; Lewis-DM
FASEB J 2002 Mar 16(5):A958
Considerable attention has been paid to potential human health hazards arising from N,N-dialkyldithiocarbamate (DTC) type vulcanization accelerators in latex products. A commonly used accelerator zinc diethyldithiocarbamate (ZDEC) has been detected in leachates from medical devices including gloves and surgical drains. It and several other zinc DTCs have been found to be causative agents of allergic contact dermatitis. Quantitation of these compounds is complicated by their labile nature and thermal instability. A simple assay was used to screen fourteen brands of condoms for zinc DTCs. After acetonitrile extraction the extracts were treated with cobalt chloride to effect formation of cobalt DTC from zinc DTC. A green colored solution suggested the presence of a DTC while blue indicated a negative result. Six positive results were observed and two of these were confirmed to contain ZDEC by GC/MS. ZDEC concentrations were determined by measuring UV absorbances of transmetalated samples at 320 nm. When analyzing large numbers of samples this preliminary screening method should prove useful for identifying latex products with free DTCs.
Health-hazards; Hazards; Zinc-compounds; Medical-equipment; Dermatitis; Allergic-dermatitis; Sampling; Sampling-methods; Gloves; Contact-dermatitis; Allergens
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Abstract; Conference/Symposia Proceedings
The FASEB Journal, Experimental Biology 2002, New Orleans, Louisiana, April 20-24, 2002